The following three papers provide an excellent insight/mechanism of how penicillin binding protein 2a (Pbp2a) of S. aureus possesses an allosteric site that can be bound by peptidoglycan substrate and inhibitor such as ceftaroline (a new generation cephalosporin) and it control structure/activity of the catalytic site (60 angstroms away). Together these three papers make a great example of bench-to-bedside scientific literature and a good journal club discussion.
The PMID # for the three papers are 24085846, 24955778 and 25155594. Click on the PMID # to access PubMed link to the papers.
No comments:
Post a Comment